Nasal carriage of Staphylococcus aureus treated with topical mupirocin (pseudomonic acid) in a children's hospital
2% mupirocin ointment applied intra-nasally for 5 days was assessed for elimination of nasal carriage of Staphylococcus aureus in 31 staff members in a children's hospital. Three volunteers failed to complete the trial because of side effects, i.e. buccal reddening and swelling, and unpleasant taste. During treatment staphylococcal nasal carriage was not found in any case; of the 24 post-treatment nasal swabs taken 4 days after treatment 22 were still negative. Re-colonization with S. aureus of different phage types occurred in the remaining two cases.
|Keywords||administration, intranasal, antibiotics/administration & dosage/pharmacology, carrier state, child, cross infection/prevention & control, fatty acids/administration & dosage/pharmacology, female, hospitalization, human, male, mupirocin, nose/microbiology, staphylococcal infections/prevention & control, staphylococcus aureus/drug effects|
Frank, U., Lenz, W., Damrath, E., Kappstein, I., & D. Daschner, F.. (1989). Nasal carriage of Staphylococcus aureus treated with topical mupirocin (pseudomonic acid) in a children's hospital. Journal of Hospital Infection, 13(2), 117–120. Retrieved from http://hdl.handle.net/1765/7052