Synaptic transmission is highly dependent on recent activity and can lead to depression or facilitation of synaptic strength. This phenomenon is called "short-term synaptic plasticity" and is shown at all synapses. While much work has been done to understand the mechanisms of shortterm changes in the state of synapses, short-term plasticity is often thought of as a mechanistic consequence of the design of a synapse. This review will attempt to go beyond this view and discuss how, on one hand, complex neuronal activity affects the short-term state of synapses, but also how these dynamic changes in synaptic strength affect information processing in return.

doi.org/10.1523/JNEUROSCI.3348-12.2012, hdl.handle.net/1765/71046
The Journal of Neuroscience
Department of Neuroscience

Klug, A., Borst, G., Carlson, B., Kopp-Scheinpflug, C., Klyachko, V., & Xu-Friedman, M. (2012). How do short-term changes at synapses fine-tune information processing?. The Journal of Neuroscience, 32(41), 14058–14063. doi:10.1523/JNEUROSCI.3348-12.2012