Objective: A role for the angiotensin-converting enzyme (ACE) gene has been suggested in the aetiology of type 2 diabetes (T2DM). However, results have been inconsistent. In this study, we performed a meta-analysis to further clarify the association between ACE I/D polymorphism and T2DM risk in a Chinese population. Methods: PubMed, EMBASE, CNKI and Wan Fang Data were searched for eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a fixed-effects model or random-effects model. Results: A total of 41 studies (4708 cases and 5368 controls) for the association between ACE I/D polymorphism and T2DM in a Chinese population were identified. The pooled ORs for the association between ACE I/D polymorphism and T2DM risk were not statistically significant under all genetic models (co-dominant model: DD vs. II: OR = 1.17, 95% CI 0.97-1.42 and ID vs. II: OR = 1.01, 95% CI 0.93-1.10; dominant model: OR = 1.06, 95% CI 0.94-1.19; multiplicative model: OR = 1.08, 95% CI 0.98-1.18). Although a marginally significant association was observed under a recessive model (OR = 1.17, 95% CI 1.00-1.36), robustness of this estimate could not be established under additional sensitivity analyses. Conclusions: The meta-analysis presented in this study indicated that ACE I/D polymorphism may not be associated with the risk of T2DM in the Chinese population.

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doi.org/10.1177/1470320311435535, hdl.handle.net/1765/71415
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Erasmus MC: University Medical Center Rotterdam

Zhou, D., Ruiter, R., Zhang, J., Zhou, M., Liu, H., Liu, W., & Wang, S. (2012). Angiotensin-converting enzyme I/D polymorphism is not associated with type 2 diabetes in a Chinese population. JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, 13(3), 372–378. doi:10.1177/1470320311435535