Purpose: To investigate the prevalence of intraocular infections after allogeneic stem cell transplantation (allo-SCT). Methods: The study design was a single institutional retrospective noncomparative cohort of 135 consecutive patients in 2006 and 2007 who underwent allo-SCT for hematological malignancy. The primary outcome was the development of intraocular infections after allo-SCT and secondary outcome consisted of development of other ocular disorders during follow-up. Results: The most frequent ocular sequel to allo-SCT included ocular graft-versus-host disease (GvHD), which developed in 37/135 patients (27%). Intraocular infection occurred in 1 of 135 patients (0.7%). This patient developed infectious chorioretinitis together with osteomyelitis, endocarditis, and brain abscess with fungus Scedosporium and was successfully treated with a combination of voriconazole, amphotericine B, and surgical interventions. Viral and/or bacterial intraocular infections were not observed at all. Conclusions: Intraocular infections after allo-SCT are currently uncommon due to systematic use of preemptive treatment regimens, frequent controls, and early treatment of systemic infections.

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doi.org/10.3109/09273948.2013.827216, hdl.handle.net/1765/73127
Ocular Immunology and Inflammation
Department of Ophthalmology

Stoyanova, V., Riemens, A., Lokhorst, H., te Boome, L., & Rothová, A. (2014). Absence of intraocular infections after hematopoietic stem cell transplantation at a single center: The experience with current preventive regimens. Ocular Immunology and Inflammation, 22(2), 116–120. doi:10.3109/09273948.2013.827216