background In adults, low level of education was shown to be associated with higher blood pressure levels and alterations in cardiac structures and function. It is currently unknown whether socioeconomic inequalities in arterial and cardiac alterations originate in childhood. Therefore, we investigated the association of maternal education with blood pressure levels, arterial stiffness, and cardiac structures and function at the age of 6 years and potential underlying factors. methods The study included 5,843 children participating in a prospective cohort study in the Netherlands. Maternal education was assessed at enrollment. Blood pressure, carotid-femoral pulse wave velocity, left atrial diameter, aortic root diameter, left ventricular mass, and fractional shortening were measured at the age of 6 years. results Children with low educated (category 1) mothers had higher systolic (2.80 mm Hg; 95% confidence interval (CI) = 1.62-2.94) and diastolic (1.80 mm Hg; 95% CI = 1.25-2.35) blood pressure levels compared with children with high educated (category 4) mothers. The main explanatory factors were the child's body mass index (BMI), maternal BMI, and physical activity. Maternal education was negatively associated with fractional shortening (Ptrend = 0.008), to which blood pressure and child's BMI contributed the most. No socioeconomic gradient was observed in other arterial and cardiac measurements. conclusions Socioeconomic inequalities in blood pressure are already present in childhood. Higher fractional shortening among children from low socioeconomic families might be a first cardiac adaptation to higher blood pressure and higher BMI. Interventions should be aimed at lowering child BMI and increasing physical activity among children from low socioeconomic families.

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doi.org/10.1093/ajh/hpt180, hdl.handle.net/1765/73209
American Journal of Hypertension
Department of Pediatrics

Bouthoorn, S., van Lenthe, F., de Jonge, L., Hofman, A., van Osch-Gevers, L., Jaddoe, V., & Raat, H. (2014). Maternal educational level and blood pressure, aortic stiffness, cardiovascular structure and functioning in childhood. American Journal of Hypertension, 27(1), 89–98. doi:10.1093/ajh/hpt180