Multimodality Imaging and Clinical Implications of Bioresorbable Scaffolds in Complex Coronary Artery Disease

Abstract

Fully bioresorbable scaffolds (BRS) are a novel therapeutic approach to coronary artery disease as they provide transient vessel support in contrast to the permanent caging by metallic stents. In 2006, the fully bioresorbable everolimus-­‐eluting polylactide scaffold, namely the Absorb BVS, was introduced. This novel technology has been extensively investigated in the ABSORB Clinical Program, in that the first-­‐in-­‐man ABSORB Cohort B trial using the current generation BVS showed excellent clinical results in terms of safety and efficacy. Then this device has been widely used in the clinical setting. The aims of the thesis are 1) to understand the concept, mechanical properties, methodologies for multimodality imaging assessment, and clinical performance of the fully bioresorbable everolimus-­‐eluting polylactide scaffold; 2) to investigate advanced three-­‐dimensional imaging techniques for anatomical and functional lesion assessment; 3) to discuss the methodology of light-­‐based imaging assessment for patients with ST-­‐segment elevation myocardial infarction (STEMI); and finally 4) to explore the clinical implications in more complex subsets of lesions/patients and future therapeutic potentials of this technology.