Detection of HPV-16 DNA by PCR in histologically cancer free lymph nodes from patients with cervical cancer
The prognostic value of detection of human papillomavirus (HPV) type 16 DNA in histologically cancer free lymph nodes was assessed in left obturator lymph nodes from cervical cancer patients with HPV-16 positive primary tumours. HPV-16 DNA was detected by polymerase chain reaction in 12 of 35 patients with histologically cancer free lymph nodes. Of these 12 patients, only one developed a recurrence, suggesting HPV-16 DNA detection in cancer free lymph nodes has no prognostic value.
|Keywords||Carcinoma, Squamous Cell/*virology, DNA, Viral/*analysis, Female, Follow-Up Studies, Humans, Lymph Nodes/*virology, Papillomaviridae/classification/*isolation & purification, Pelvis, Polymerase Chain Reaction, Prognosis, Uterine Cervical Neoplasms/*virology|
Baay, M.F.D., Koudstaal, J., Hollema, H., Duk, J.M., Burger, M.P.M., Quint, W.G.V., … Herbrink, P.. (1997). Detection of HPV-16 DNA by PCR in histologically cancer free lymph nodes from patients with cervical cancer. Journal of Clinical Pathology: an international peer-reviewed journal for health professionals and researchers in clinical pathology. Retrieved from http://hdl.handle.net/1765/8744