HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein
Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clearance of respiratory syncytial virus (RSV) infection. We have generated cytotoxic T-cell clones (TCC) from two infants who had just recovered from severe RSV infection. These TCC were functionally characterized and used to identify HLA class I (B57 and C12)-restricted CTL epitopes of RSV.
|Keywords||Epitope Mapping, Epitopes, T-Lymphocyte/*immunology, Histocompatibility Antigens Class I/*immunology/metabolism, Humans, Infant, Infant, Newborn, Research Support, Non-U.S. Gov't, Respiratory Syncytial Virus Infections/virology, Respiratory Syncytial Viruses/*immunology, T-Lymphocytes, Cytotoxic/*immunology, Viral Fusion Proteins/*immunology, Viral Proteins/*immunology|
Brandenburg, A.H., de Waal, L., Timmerman, H.H., Hoogerhout, P., de Swart, R.L., & Osterhaus, A.D.M.E.. (2000). HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein. Journal of Virology. Retrieved from http://hdl.handle.net/1765/9483