Buijs, D.

paclitaxel plasma patient concentration cancer pharmacokinetic administration sparreboom sample infusion cremophor el blood taxol cremophor level verweij plasma samples paclitaxel fu dialysis 3- h i.v equilibrium dialysis value clearance study disposition equilibrium dose levels 225 mg /m oncol brouwer rotterdam presence g -3h result dosing nooter method stoter cavity binding distribution function fraction tumor exposure profile bioavailability treatment loos wj toxicity plasma concentration stoter g scintillation curve equilibrium dialysis method phase range 135 mg /m gianni intraperitoneal 125 mg /m rotterdam cancer institute 6 mg /ml nooter k drug administration cancer patients vehicle table crel concentration verweij j pharmacol paclitaxel disposition concentration-time measurement paclitaxel concentration walle formulation micelle experiment anticancer