Prins, S.A.

patient children propofol sedation midazolam infant study level value paracetamol concentration scale score effect model comfort infusion sedative care unit bis values pharmacokinetic surgery rectal population parameter administration propacetamol index bispectral bispectral index group chapter monitoring correlation comfort behavior scale analgesia barbiturate figure comfort-b behavior craniofacial surgery range analysis blood anesthesia month postoperative rectal paracetamol variability clearance adult plasma table observation sr-bi propofol infusion sr-eeg morphine assessment barbiturate coma craniofacial anaesth treatment comfort scale period comfort behavior scores 2 years paediatric pediatr volume ventilation response care patients 1 year difference function ramsay sedation scale auditory pharmacodynamic metabolite