Rombouts, W.J.C.

patient leukemia 3/itd sample tandem duplications mutation myeloid leukemia myeloid flt 3 gene duplication tandem flt 3 flt 3/itds blood factor receptor group expression study response /scid flt 3/itd survival analysis kinase flt 3/itd aml population cxcr -4 cytogenetic hematopoietic cxcr -4 expression tyrosine prognosis aml cells culture chapter marrow growth proliferation cytokine 3-gene number 0.1 tandem duplication nod /scid mice aml samples cd 34+ cells ability table presence engraftment correlation relapse level leukemic domain therapy ploemacher re class figure bone marrow 34+ differentiation flt 3-gene effect whilst model prognostic value patient prognosis c-kit adult flt 3/wt aml flt 3 ligand aml patients proliferative lowenberg b progenitor myeloid leukemia cells result