Okamura, H.

protein mper 2 clock circadian mcry 1 hsd 3b mper 1 localization expression nucleus cos 7 cells cry-null mice mcry proteins analysis domain gland level cry-null ha-cry mper 3 sequence mper 2 protein antibody subcellular localization serum shock presence zona glomerulosa cells subcellular c terminus figure aldosterone cytoplasmic glomerulosa 1/mcry ubiquitylation mper proteins accumulation export mouse serum mechanism mper 2. science transfected study result degradation entry blot analysis circadian clock absence c-terminal translocation system –/– mper 2 proteins experiment shock activity pressure oscillator signal region probe terminus c-terminal extension 1mutnlsc van der horst control ha-cry 1mutnlsc staining wild-type blood pressure /bmal rhythm transcription vagal immuno fluorescence pictures ubiquitylated mper 2 shearman