Spillantini, M.G.

patient inclusion family frontotemporal dementia brain dementia frontotemporal mutation tau gene chromosome disease ubiquitin-positive region atrophy cortex linkage analysis neurone study motor neurone disease tau mutations protein marker antibody onset family members spillantini tau-negative inclusions heutink neurol score swieten symptom memory van swieten jc cytoplasmic ubiquitin-positive inclusions parkinsonism ftd cases entorhinal cortex member feature tau protein layer dentate gyrus isoform ftd families 2 receptors presence acta neuropathol tau-negative nucleus hyperorality motor -17 staining rizzu p van swieten speech p 301s mutation ubiquitin pathology evidence lewy bodies problem cytoplasmic murrell jr neurofibrillary tangles tau pathology ftdp -17 tau-related ftd netherland netherlands brain bank rosso stevens m striatal dopamine ubiquitin inclusions lod scores pcr products kovari kertesz