Smit, L.

b cells e 41k btk – background expression btk – mice wt-hbtk response e 41k mice figure spleen kinase level background antigen bone marrow e 41k btk transgene tyrosine b cell development b 220ϩ cells mutation protein b cell areas receptor e 41k mutation splenic anti-cd number domain bruton table i development hendrik btk ϩ background marrow x-linked agammaglobulinemia natl acad btk ϩ fragment serum antibody effect immunol b cell numbers defect splenic b cells x-linked fl ow cytometry culture anti-igm t cells class stimulation ficient signi ficantly anti-cd 40 signal signi population recirculating fi ndings phenotype mouse value concentration presence splenic architecture e 41khbtk mice src family kinases moma -1ϩ cells speci activation igg 1 b cell responses overexpression control surface result drabek ti-ii