Tolhuis, B.J.

globin transcription locus chromatin globin genes fragment factor element protein globin locus interaction expression cis-regulatory dna elements figure promoter region control erythroid frequency cross-linking sequence erythroid cells enhancer mouse grosveld f cross-linking frequencies cis-regulatory histone transcriptional level hypersensitive domain chapter trans-acting factors model hypersensitive sites structure binding compartment activity beta-globin space transcription factors looping nucleus regulation cross-linking frequency chromosome result grosveld addition trans-acting liver dnase dynamic heterochromatin restriction formation expression levels globin gene chromatin structure number genen brain activation hindiii cluster groudine m component deletion study effect development transgene function position distance ligation conformation analysis