Henthorn, P.

deletion sequence breakpoint fragment figure probe globin cluster hpfh 1 region clone &3-thal ill-barn hi fragment hpfh 2 phage orkin eco ri nature dna sequences point family alu sequence hybridization chromosome exchange result rearrangement deletion joints mechanism relationship flavell breakage order nucleotide van der ploeg hpfh 1 deletion length hpfh 2 homozygote replication restriction enzyme sites fritsch y &3-thal 1 alu family sequence nonhomologou figure 3 persistence nucleotide sequences thalassemia distance cosmid clones anchorage genomic anchorage points enzyme restriction hybridize hemoglobin reunion hpfh 1 dna fibroblast cell line 50 pg /ml hpfh 2 deletion laboratory nonhomologous exchanges denatured nick-translated probe @- globin gene hpfh 2 dna /3- globin gene joint genomic dna acids res probe 1 jagadeeswaran 13 kb fragment event ybp-thal 1 deletion alu family sequences hpfh deletions reunion event thalassemia cases