Stam, T.C.

patient leakage tumor necrosis factor level perfusion tumor leakage patients necrosis limb perfusion toxicity factor cytokine protein grade minute il -6 10 patients melphalan phase il -8 value c-reactive protein blood response administration sarcoma tnf levels oncol spla 2 cancer study schraffordt koops h 30 minutes melanoma concentration perfusate circulation hypotension range time points c-reactive fluid detection limit eggermont interleukin ann surg oncol table result shock peak levels nonleakage patients effect 7 days blood pressure release liter treatment group 3 hours exposure limit point pattern lienard detection plasma immunol il -6 levels s-phospholipase fluid challenge isolation perfusion tnf concentrations ilp 3 h temperature blood transfusion service nonleakage 2.6 5 n 4 hours 10 minutes cytokine levels