Joosse, M.

mutation patient protein family study disease dementia chromosome sequence region analysis brain marker p 301l mutation transcript frontotemporal dementia antibody genomic family history clone tau protein microtubule frontotemporal 4 r tau tau gene isoform genet alzheimer netherland deletion p 301l protein tau-p onset candidate prevalence c 7orf tau mutations microtubule assembly identi presenilin position family members microtubule-associated protein tau goedert p 301l patients change function assembly table population history library product diagnosis neurol identi fied neuron polymorphic markers individual p 301l tau member cortex c 7orf transcripts control disorder genetic polymorphic contig ppd candidate region primer tau-p 301l antibodies nucleotide chorea fragment filament missense p 301l effect heutink symptom