Craig, W.A.

combination agent regimen efficacy combination therapy model value combination regimens therapy antimicrobial agents regression result antimicrobial regression analysis time mic time 0.25 agents chemother efficacie method dosing antibiotic ciprofloxacin 0.25 synergism analysis dosing regimens concentration chemother antimicrob interaction single-agent tobramycin ticarcillin ceftazidime pharmacodynamic synergy auc /mic pseudomonas aeruginosa indices aeruginosa effect response netilmicin american society animal log auc mouton pseudomona presence single-agent regimens point function study microbiology approach curve relationship strain beta-lactam single-agent therapies pharmacodynamic indices regression models log auc /mic e test animal model activity datum point interscience conference 0.5 mg /liter variation parameter craig aminoglycoside infection addition american /liter comparison index society