Herpen, E. van

mutation protein patient disease brain tau gene microtubule tau protein dementia isoform tau mutations filament study frontotemporal dementia model family antibody frontotemporal pathology mouse level chapter alzheimer goedert -17 fragment binding inclusion expression ftdp -17 system neurol figure phosphorylation 4 r tau exon 10 tau pathology effect neuron tau isoforms change l 315r mutation spillantini rosso disorder novel kinase assembly animal tau proteins neurodegenerative disorders cortex neurodegenerative formation experiment result heutink chromosome region microtubule assembly glial group swieten control promoter supranuclear palsy p 301l analysis neurodegeneration microtubule-associated protein tau sequence mouse models microtubule binding degradation p 301l mutation hutton degeneration calpain parkinsonism ftdp -17 patients