Groot, F.M.H. de

lurtotecan sample nx 211 blood light concentration patient cancer camptothecin infusion study blood samples solution plasma laboratory light mec concentrations compound product topoisomerase volume sodium light phase i increase ambient temperature 50- l aliquots 30- min i.v laboratory dilution analogue plasma samples analysis exposure phase chemical qc samples inhibitor netherland incubation camptothecin analogues topotecan activity degradation sodium ammonium university hospital rotterdam photodegradation 1- ml volumes cytotoxicity structure aliquots formulation pharmacokinetic 5 min hplc system antitumor liposomal water method cell lines liver microsomes rotterdam agent acetate system presence lactone moiety verweij condition assay stability administration extract ambient cell growth nx 211. 2- h incubation preparation sparreboom pharmacokinetic study