Calzolari, R.

globin β- globin gene locus region β- globin locus deletion γ- globin genes fragment expression mouse transcription ∆-2.5 kb yac level d.p.c grosveld effect line 3 liver analysis number signal adult figure control thalassemia blood sequence hemoglobin δ- globin gene wijgerde experiment position transcript persistence dillon yeast ∆-2.5 γ- globin gene line 13 14.5 d.p.c adult blood probe 2.5 stamatoyannopoulo ecori 14.5 δβ- thalassemia position effects plasmid γ- genes table stage 10.5 d.p.c liver cells hybridization milot development chromosome dnase β- globin genes wild-type activation element ef ficiency interaction natl acad transcription signal table ii fraser stroubouli peterson breakpoint mechanism promoter hybridized ficiency 16.5 anagnou chromatin 10.5