Santos, R.L.P.

family hearing variant marker mutation impairment frequency genet analysis sequence genome linkage protein allele hearing impairment study locus population region individual novel chapter family members deafness score prevalence connexin genotype recessive genome scan autosomal pedigree member sequence variants multipoint patient interval chromosome non-syndromic hearing loss gjb 2 multipoint linkage analysis pakistani table van camp g genome scan markers mapping phenotype figure arnshi haplotype linkage analysis gjb 2 gene program leal sm linkage-physical map multipoint lod score sequencing pakistan gjb 2 mutations result audiometric pakistani families effect disease control allele frequencies threshold number cause lod score gjb 2 variants audiogram connexin 26 mutations screening sample marker allele frequencies genomic dna research three-unit support interval