Botma, G.J.

promoter activity lipase hepatic cholesterol hepg 2 cells expression hepatic lipase liver j lipid res region hl activity protein level sequence hl gene plasma effect hl promoter activity study lipid allele variant patient adrenal hepatic lipase gene control subject polymorphism transcription chapter group factor lipoprotein hdl cholesterol jansen hepatic lipase activity binding type 2 diabetes promoter activity hl expression hl promoter insulin genotype disease jansen h variant hl mrna intron hl mrna j biol chem fragment hdl group atherosclerosi concentration substitution srebp element product hl promoter region oligonucleotide diabetes rat adrenals hdl cholesterol levels regulation transcriptional cholesterol transport verhoeven rat hl gene assay promoter region transcriptional activity increase -480 t-allele number analysis experiment synthesis figure result