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Ward, A.C.

(Alister Ward)


receptor g-csf-r g-csf activation factor tyrosine blood granulocyte colony-stimulating factor granulocyte mutation internalization colony-stimulating protein domain myeloid figure differentiation kinase proliferation signal response stat 3 pathway expression patient gcsfr neutropenia j biol chem stat 3 activation number growth cytokine analysis stat 5 study leukemia region clone jak-stat binding progenitor result colony antibody jak-stat pathway survival stat activation level touw ip wt g-csf-r /egfp ligand marrow stat 5 activation cytoplasmic panel /egfp hematopoietic 715 mice wild-type distribution phosphorylation mutant receptor tyrosines constitutive mol cell biol 715/ 715 mice activity p 206h mutation presence receptor internalization motif addition scn patients interferon stat 1 receptor activation myeloid leukemia constitutive activation concentration embo j




6 Most Recent Publications

Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics (Article)
Aarts, L.H.J. Roovers, O. Ward, A.C. Touw, I.P.
2004-01-01
Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells (Article)
Hermans, M.H. Heijmans-Antonissen, C. Gits, J. Leeuwen, D. van Ward, A.C. Touw, I.P. Geijn, G.J.M. van de
2003-01-01
The Jak-Stat pathway in normal and perturbed hematopoiesis (Article)
Ward, A.C. Yoshimura, A. Touw, I.P.
2000-01-01
Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene (Article)
Hermans, M.H. Heijmans-Antonissen, C. Ward, A.C. Mayen, A.E. Ploemacher, R.E. Touw, I.P.
1999-01-01
Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells (Article)
Ward, A.C. Smith, L. Koning, J.P. de Touw, I.P. Aesch, Y.M. van
1999-01-01
Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment (Article)
Ward, A.C. Aesch, Y.M. van Gits, J. Schelen, A.M. Koning, J.P. de Leeuwen, D. van Freedman, M.H. Touw, I.P.
1999-01-01
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