Smith, L.

g-csf-r tyrosine differentiation receptor proliferation domain g-csf survival tyr -704 response signal receptor tyrosines clone mutant analysis blood cytoplasmic activation sh 2 domains stat 3 activation erasmus mc stat 3 tyr 3 phe tyr -764 study membrane-distal domain addition pathway -704 expression protein grb 2 myeloid membrane-distal neutrophilic differentiation molecule concentration erasmu neutrophilic rpmi 1640 medium factor kinase binding tyr -764. cytoplasmic tyrosines 8.6 -764 result tyrosine-independent www.jbc.org december function pawson contribution region downloaded library g-csf concentrations lowenberg sds-polyacrylamide gel electrophoresis maturation-competent myeloid 32 add-back mutants g-csf-r tyrosine mutants g-csf-mediated medium tyr -744 antibody 32 p-labeled 100 ng /ml membrane-distal region shp -2 tyr -729 nagata production myeloid 32 ligand sh 2 domain tyrosine-independent differentiation domain glutathione s-transferase fusions transfectant