Koning, J.P. de

g-csf-r receptor g-csf activation factor tyrosine differentiation protein proliferation domain granulocyte region stat 3 granulocyte colony-stimulating factor signal figure growth cytoplasmic colony-stimulating expression kinase binding mutation myeloid p 21 r complex response blood pathway antibody mutant baf 3 cells grb 2 phosphorylation stat 3 activation neutrophilic tyrosine phosphorylation il -3 c-terminal clone residue neutrophilic differentiation formation induction result wild-type lowenberg b transduction neutropenia transfectant level myeloid cells cytokine medium control stimulation g-csf-induced substitution murine sh 2 domains van buitenen c cytoplasmic domain wt g-csf-r c-terminal region y 764 minute transcription touw ip lowenberg mechanism oligonucleotide association cycle g-csf stimulation function ligand analysis sequence tyrosine residues survival