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tuberin rearrangement hamartin analysis recombination expression t-cell t-all protein patient sample leukemia mef 2c figure intronrs result study variant gst -14-3-3 beads table signal interaction binding identi fied cluster sb analysis rss-intronrs clonal phosphorylation 2-1 identi translocation pattern control beads clonality cell lines lysate joint chaperone function segment lymphoblastic leukemia multiplex primers blood locus substitution pcr products tsc 1 nkx 2-1 level lmo 2 1.3/2.3 region tuberinhamartin rss-kde r 905q variants wild-type tuberin igk recombinations product -14-3-3 function receptor sequence chaperone cancer v 769e variants 14-3-3 probe biomed tuberin variants erasmus mc blot analysis pcr analysis chain immunoglobulin expression pattern oncogene tyrosine van dongen jj
8 Most Recent Publications
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Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
(Article)
Homminga, I. Pieters, R. Vlierberghe, P. van Ferrando, A.A. Cayuela, J.M. Verhaaf, B. Beverloo, H.B. Horstmann, M. Haas, V. de Wiekmeijer, A.-S. Pike-Overzet, K. Staal, F.J.T. Langerak, A.W. Laat, W.L. de Soulier, J. Sigaux, F. Meijerink, J.P.P. Rooi, J.J. de Stubbs, A. Verstegen, M.M.A. Vuerhard, M.J. Buijs-Gladdines, J.G.C.A.M. Kooi, C. Klous, P. |
2011-04-12
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T-cell receptor Vβ CDR3 oligoclonality frequently occurs in childhood refractory cytopenia (MDS-RC) and severe aplastic anemia
(Article)
Vries, A.C. de Langerak, A.W. Heuvel-Eibrink, M.M. van den Verhaaf, B. Niemeyer, C.M. Stary, J. Schmiegelow, K. Wering, E.R. van Zwaan, C.M. Beishuizen, A. Pieters, R. |
2008-06-01
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Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL
(Article)
Dik, W.A. Nadel, B. Langerak, A.W. Przybylski, G.K. Asnafi, V. Grabarczyk, P. Navarro, J.-M. Verhaaf, B. Schmidt, C.A. Macintyre, E. Dongen, J.J.M. van |
2007-07-01
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Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes
(Article)
Sandberg, Y. Verhaaf, B. Gastel-Mol, E.J. van Wolvers-Tettero, I.L.M. Vos, J. de MacLeod, R.A.F. Noordzij, J.G. Dik, W.A. Dongen, J.J.M. van Langerak, A.W. |
2007-02-01
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BIOMED-2 multiplex immunoglobulin/T-cell receptor polymerase chain reaction protocols can reliably replace Southern blot analysis in routine clonality diagnostics
(Article)
Sandberg, Y. Gastel-Mol, E.J. van Verhaaf, B. Lam, K.H. Dongen, J.J.M. van Langerak, A.W. |
2005-01-01
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Unraveling the consecutive recombination events in the human IGK locus
(Article)
Langerak, A.W. Nadel, B. Torbal, A. de Wolvers-Tettero, I.L. Gastel-Mol, E.J. van Verhaaf, B. Jäger, U. Dongen, J.J.M. van |
2004-01-01
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Identification and characterization of the interaction between tuberin and 14-3-3zeta.
(Article)
Nellist, M.D. Goedbloed, M.A. Winter, C. de Verhaaf, B. Jankie, A. Reuser, A.J.J. Ouweland, A.M.W. van den Sluijs, P. van der Halley, D.J.J. |
2002-10-18
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TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex
(Article)
Nellist, M.D. Verhaaf, B. Goedbloed, M.A. Reuser, A.J.J. Ouweland, A.M.W. van den Halley, D.J.J. |
2001-01-01
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