Goedert, M.

mutation patient family microtubule microtubule assembly protein dementia assembly tau gene p 301l mutation study goedert isoform family history dk 280 mutation microtubule-associated protein tau disease frontotemporal dementia change family members tau protein four-repeat tau isoforms sequence effect brain spillantini filament chromosome frontotemporal missense mutations missense history intronic exon 9 position four-repeat ability residue deletion member spillantini mg genet presenile dementia buffer table g 272v mutation phenotype analysis heutink goedert m tau mutations binding intronic mutations netherland alzheimer jakes r microtubule binding crowther ra group crowther hutton wild-type jakes microtubule-binding alteration rizzu 280k mutation tau mrna transcripts nucleotide 10- min centrifugation sequence alterations university hospital dijkzigt neuron neurol region sample ftdp -17 families pallido-ponto-nigral degeneration ammonium sulphate solution farlow mr