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radiological osteoarthritis osteoarthritis disability locomotor disability radiological study women locomotor association allele genotype vdr genotype bone density rotterdam osteophyte density population rotterdam study kellgren morning stivness odds ratios table stivnes score morning ratio prevalence people rheum vdr gene grade bone mineral density presence research analysis receptor hip pain vitamin participant health body mass index radiographic osteoarthritis odds ratio research centre kellgren score group knee pain subject erasmus university frequency obesity centre criteria 55 years feature arthritis hofman rheumatol function university osteoporosis odding mineral femoral neck cartilage radiographic 1994. vdr genotype frequencies nutrition examination survey-i article classification locomotor disability index allele dose effect follow-up study polymorphism variable receptor genotype bone miner interviewer relationship