Monninkhof, E.

patient exacerbation antibody pneumococcal serotype copd patients vaccine pneumococcal colonization colonization disease conjugate valent study patient group serum polysaccharide serotype 6 b adult infection vaccination state increase level response sample sputum pneumoniae antibody levels culture titer concentration pneumococci coverage effect value group hazard ratio antibody titers development 23- presence exacerbation episode igg antibodies serum samples monoculture species table 2002. high-avidity 92 copd patients vaccine serotype strains episode cross-reactive serotypes pneumococcal capsular polysaccharides 115 pneumococcal sputum samples pathogen sputa conjugate vaccine high-avidity antibody titers conjugate vaccine serotypes van der palen result g /ml statens serum institute serotypes 19 f pneumococcal infection pneumococcal serotypes hazard capsular bacteria 11- ratio children wedzicha pneumococcal disease serotype distribution streptococcus pneumoniae sputum cultures risk factor