Lynch, T.

patient mutation lrrk 2 disease 2019ser idiopathic pd onset parkinson symptom idiopathic department neurology university study family lrrk 2-associated pd centre frequency carrier dementia hospital estimate research penetrance genotype stage alzheimer qsbb series consortium parkinsonism lrrk 2 mutations series apolipoprotein group institute 10 years fference foundation scale london analysis prevalence disorder allele 79 years grant treatment genetic table 2-associated method cause ffected population disease duration 69 years article tremor pd onset duration testing di fference dystonia health progression individual incidence control symptom onset non-motor symptoms apolipoprotein e state 40 years 59 years penetrance estimates missense clinic kaplan-meier hoehn protein