Jackson, M.H.

protein pneumococcal pneumoniae strain serum opsonophagocytic activity streptococcus pneumoniae streptococcu opsonophagocytic serotype surface antibody activity pneumococcal strains sequence analysis virulence immun laboratory rabbit infection vaccine bacteria electrophoresis proteinase maturation protein brile pneumococci capsular immunoelectron microscopy pneumococcal surface protein survival time ppma antibodies buffer surface-associated study mcdaniel protection blot analysis hyperimmune fraction preimmune serum pneumococcal proteins maturation phagocytosi nucleotide fluorescein isothiocyanate-labeled bacteria acid sequence analysis sds-polyacrylamide gel electrophoresis serum opsonophagocytic activity room temperature rabbit serum response variation variant polysaccharide surface-associated proteins protein fraction ability hyperimmune serum mass spectrometry microb primers proteinase paton netherland immunoelectron overweg pathogenesis result microscopy survival model preimmune genes encoding pneumolysin pneumolysin concentration mouse pneumonia model conjugate multicomponent protein vaccines ice-cold pbs