Jenuwein, T.

globin locus b globin locus protein chromatin expression effect b globin gene concentration result background figure region dnase promoter suv 39h drosophila dnase i sensitivity transgene eklf +/± background factor centromeric number increase chromatin structure mouse ¯uence decrease control 5¢- position ¯uence pev satellite transcription pc-g proteins chromatin ® bres b globin promoter variation erythroid wijgerde heterochromatin figure 2 pev lines change grosveld table i structure binding level activation dnase i g satellite sensitivity b-globin signal milot b globin rna pc-g proteins bmi nuclease variegation erythroid cells transcribing liver table position effect variegation dnase i hypersensitivity erythroid cells centromere homologue amount ®cation centromeric foci marin development 14.5 day line 72 modi ®cation b globin +/± study transcription factors