Hilbrands, L.B.

patient ec-mp concentration mycophenolate group mycophenolate mofetil transplant study rejection transplantation enteric-coated mycophenolate sodium pharmacokinetic mpa auc 0–12 mofetil model withdrawal transplant recipients 0–12 table csa withdrawal group transplant patients predose cyclosporine mycophenolic sampling difference recipient value absorption mpa predose concentrations result analysis estimation mycophenolic acid sodium pred withdrawal group administration parameter auc 0–12 enteric-coated number pharmacokinetic parameters morning kidney pred withdrawal ec-mps administration dataset therapy clearance graft population ec-mps-treated patients performance correlation effect randomization mpa auc comparison control group point evening precision 3 hours postdose trial mpa concentrations incidence follow-up creatinine predose concentrations budde sample validation pharmacokinet biopsy-proven infection winter serum serum creatinine drug monitoring 24 mo