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repair csbm /m mice mouse animal cancer xpc à/à mice liver protein damage −/− oxidative growth wild-type tumor xpa à/à mice van der horst csbm /m level dna damage control figure syndrome nucleotide excision repair dna repair csbm /m pups defect frequency analysis c 57bl background ageing genome excision cockayne metabolism csa −/− mice xpa à/à expression survival cockayne syndrome wk-old group oxidative metabolism +/− d-old signi tissue 0.000 synthesis table background oxidative dna damage response study patient littermate nucleotide wild-type controls photoreceptor antioxidant somatotroph axis xpc à/à csa −/− animals csbm /m animals lesion increase antioxidant defense csa +/+ exposure number photoreceptor cells death phenotype radiation skin cancer predisposition horst ficient gh /igf axis mouse csa gene hormone result
4 Most Recent Publications
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Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes
(Article)
Melis, J.P.M. Wijnhoven, S.W.P. Steeg, H. van Beems, R.B. Roodbergen, M. Berg, J. van den Moon, H. Friedberg, E.C. Horst, G.T.J. van der Hoeijmakers, J.H.J. Vijg, J. |
2008-03-01
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Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.
(Article)
Pluijm, I. van der Garinis, G.A. Niedernhofer, L.J. Velasco, S. Friedberg, E.C. Tanaka, K. Steeg, H. van Hoeijmakers, J.H.J. Horst, G.T.J. van der Brandt, R.M.C. Gorgels, T.G.M.F. Wijnhoven, S.W.P. Diderich, K. Wit, J. de Mitchell, J.R. Oostrom, C.T.M. van Beems, R.B. |
2006-12-12
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UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.
(Article)
Meira, L. Gorgels, T.G.M.F. Friedberg, E.C. Horst, G.T.J. van der Wit, J. de Velasco-Miguel, S. Richardson, J.A. Kamp, Y. Vreeswijk, M.P. Smit, B. Bootsma, D. Hoeijmakers, J.H.J. |
2002-05-16
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Molecular aspects of DNA repair.
(Article)
Friedberg, E.C. Backendorf, C.M.P. Burke, J.F. Collins, A. Grossman, L. Hoeijmakers, J.H.J. Lehmann, A.R. Seeberg, E. Schans, G.P. van der Zeeland, A.A. van |
1987-01-01
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