Jagmohan, S.

cancer family breast mutation breast cancer colorectal cancer colorectal patient cohort meijers-heijboer hnpcc phenotype hnpcc-like disease colorectal cancer cases hbcc phenotype criteria age !60 years breast cancer risk carrier genet disease table brca 1 age 60 years non-brca 1/brca rotterdam allele age 50 years prevalence chek 2 hbcc criteria hnpcc-like report vasen pathway checkpoint tumor noncarrier diagnosis wijnen rotterdam family cohorts mlh 1 mutation intra-s phase checkpoint dutch founder mutations meijers-heijboer h index cases non-hbcc breast cancer cases study endometrial cancer msh 6 mutation msh 6 genes index 55 families hbcc breast cancer msh 2 mutation difference breast cancer diagnosis dutch cosegregation brca 2 mutations saccharomyces cerevisiae non-hbcc breast cancer vasen h department vahteristo fodde clinic susceptibility presence genome instability cycle phase carcinoma li-fraumeni syndrome variant erasmus mc disease phenotype coding sequences