Melissen, P.M.

mtppe infection number effect inoculation macrophage liposomes administration blood bacteria resistance pneumoniae le-mtppe liver spleen leukocyte muramyl treatment c 57bl mice survival study mouse pbs-treated mice cba mice figure monocyte granulocyte ifn--y pbs-treated defense liposome-encapsulated mtppe pneumoniae infection intracellular factor table dipeptide lymphocytes muramyl dipeptide immunomodulator muramyl peptides lipid tissue macrophages result ifn-y 120 h dose range activity model agent organ tissue efficacy 3.1 patient peptide 103 cfu k interferon immunocompromised patients tripeptide immun uptake activation immunocompromised significance control chapter *** liposomal control mice host defense septicemia liposome-encapsulated form importance liposomal encapsulation cell types tumor necrosis factor virus observation stimulation addition