Ronteltap, C.

lymphocytes receptor affinity t lymphocytes scfvg mage-a tumor melanoma hla-a chimeric cd 28 target production response tcr-like scfvhyb chain cytokine level immunol t cells cancer tumor cells peptide antibody element specificity expression t-cell costimulatory cytokine production activity 2002. mage-a 1neg ag bolhui 1/mage willemsen cytolytic affinity scfvg 8cd il -2 production class il -2 2001. target cells affinity maturation transductant capacity domain vector cancer res molecule tumor-specific display costimulation transfer tetramer 2.2 immunology activation affinity scfvg 8- target cell ratios mage-a 1 peptide affinity scfvcd 28 fc ri transduced 51 cr release affinity scfvhyb 3cd mage-a 1 patient t lymphocyte transductants phage cd 28 vs scfvhyb 3- pos antigen metastatic melanoma cytokine production levels transduced t lymphocytes signal t cell transductants tumor-specific t lymphocytes