Kremer, H.P.

patient mutation dementia study disease family prevalence frontotemporal dementia netherland family history diagnosis tau mutations frontotemporal alzheimer centre analysis neurol onset history 100 000 inhabitants spastic paraparesis 100 000 neurology ubiquitin-positive inclusions population presenilin prevalence estimates estimate brain autosomal criteria tau mutation analysis study centre ftd patients / csf studies p.l 424r mutation tau gene identi impairment symptom zuid-holland rosso inhabitants biomarker inclusion range tau mutation dna diagnosis group spastic protein tauopathy age 60±69 years table ubiquitin-positive research reference course non-referral autopsy p-tau r 406w frequency p.l 424r dk 280 paraparesi series misdiagnosi concentration poorkaj physician atrophy number level january radboud university nijmegen reference values province gait dif ficulties phenotype