Anderson, B.J.

clearance concentration morphine neonate pharmacokinetic model parameter paracetamol study litre children 70 kg estimate population covariate variability tramadol infant patient volume effect value rectal metabolite surgery weight cl 2m function adult score analysis distribution preterm preterm neonates drug clearance table maturation population parameter variability cyp 2d polymorphisms administration litres h 1 propacetamol formation serum plasma vancomycin creatinine amikacin birth pharmacol group activity creatinine clearance covariate analysis month fi ltration rate 70- kg person figure half-life tramadol clearance change rectal paracetamol growth absorption erasmus university rotterdam impact polymorphism postnatal university postmenstrual age allegaert postnatal age loading dose rectal treatment group m 1 metabolite elimination maturation half-life variance craniofacial surgery colleague