Holford, N.H.

morphine 70 kg clearance litre litres h 1 metabolite concentration adult parameter pharmacokinetic estimate model serum formation volume children distribution maturation study creatinine elimination maturation half-life cl 2m colleague infant infusion effect 70- kg person formation clearance weight clm 3g neonate change creatinine clearance bilirubin value function posteriori bayesian estimates birth elimination clearance table surgery month morphine -6-glucuronide population half-life hydrochloride pharmacol serum concentration postnatal age loading dose morphine -3-glucuronide person morphine hydrochloride infusion metabolite elimination clearance covariate creatinine production rate 3.12 -6-glucuronide analysis glucuronide daysqln bouwmeester adult values 30 litres creatinine production 6 months morphine clearance age-related clm 6g power patient variability prediction glucuronide metabolites production bayesian tibboel metabolism allometric