Dillingh, J.H.

compound marrow activity pl 63 analogue engraftment busulfan donor bone marrow transplantation level hepsulfam transplantation treatment group assay bu analogues effect 5/5 distance treosulfan depletion cancer study cafc assay cell subsets chimerism hematopoietic blood 300 mg /kg donor marrow engraftment value allogeneic subset pharmacokinetic syngeneic table leukemia ability 3/3 property toxicity alkylating conditioning partition coefficients irradiation alkylating groups survival body irradiation internucleophile distances animal concentration cyclic coefficient syngeneic bmt myeloid leukemia ploemacher aliphatic murine 4/4 partition internucleophile sample bone marrow chimerism transplant cyclophosphamide 50 mg /kg frequency bmt conditioning therapy 150 mg /kg bone marrow cells correlation cyclohexane pharmacokinetic properties sulfamate allogeneic bmt number vivo treatment dms compounds agent control