Libutti, S.K.

tumor emap-ii perfusion tumor necrosis factor tissue limb perfusion monocyte-activating polypeptide ii effect tumor cells factor necrosis response sarcoma medium transfected study animal wild-type growth melphalan model tnf therapy transfected tumor cells antitumor tumor response wild-type tumor tissue sarcoma treatment cytokine polypeptide diameter transfection transfected tumor expression result oncol minute therapy netherland protein control cancer section eggermont tissue sarcomas growth rate patient tumor growth 10 minutes method monocyte-activating procoagulant activity production tissue factor tnf ilp -175 receptor sensitivity activity alexander hr tumor vasculature mechanism upregulation concentration tnf perfusion circuit 1 g /ml 120 g injection emap-ii production ann surg oncol 800 g /ml upregulate tnf receptor antitumor effects huvec 1 hour experiment laboratory response rate tumor volume 5 minutes