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patient b-cell b cells rearrangement figure deletion region memory mutation locus expression blood immunol artemi igh locus genomic antibody memory b cells response subset analysis distance pro-b cells b lymphocytes defect control proliferation element receptor lymphocytes recombination immunoglobulin antigen sequence number study pro-b level protein cd 19 chain development differentiation ficiency result frequency chromatin breakpoint deficiency probe disease segment 4*02 replication history bone marrow signal vh regions marker factor model replication allele function ig gene rearrangements history marrow genomic separation identi identi fied immunode stage center b cell development t-cell transcription transcript mouse cd 127ϫ cells immunodeficiency process
10 Most Recent Publications
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Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity
(Article)
Driessen, G.J.A. IJspeert, H. Zelm, M.C. van Dongen, J.J.M. van Deuren, M. van Burger, C.W. Weemaes, C.M.R. Haraldsson, A. Trip, M. Warris, A. Flier, M. van der Wulffraat, N.M. Verhagen, M.M.M. Taylor, M.A. |
2013-04-08
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Perigranuloma localization and abnormal maturation of B cells emerging key players in sarcoidosis?
(Article)
Kamphuis, L.S. Zelm, M.C. van Hagen, P.M. van Laar, J.A.M. van Lam, K.H. Rimmelzwaan, G.F. Baarsma, G.S. Dik, W.A. Thio, H.B. Daele, P.L.A. van Velthoven, M.E. van Batstra, M.R. |
2013-02-15
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New frontiers of primary antibody deficiencies
(Article)
Burger, C.W. Zelm, M.C. van Driessen, G.J.A. Dongen, J.J.M. van |
2012-01-01
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B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency
(Article)
Driessen, G.J.A. Zelm, M.C. van Dongen, J.J.M. van Burg, M. van der Hagen, P.M. van Hartwig, N.G. Trip, M. Warris, A. Vries, E. de Barendregt, B.H. Pico, I. Hop, W.C.J. |
2011-12-22
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The nature of circulating CD27
+CD43
+ B cells
(Article)
Martin, P.-A. Christina, G.-W. Teodosio, C. Dongen, J.J.M. van Orfao, A. Zelm, M.C. van |
2011-12-19
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Checkpoints of B cell differentiation: Visualizing Ig-centric processes
(Article)
Berkowska, M.A. Burg, M. van der Dongen, J.J.M. van Zelm, M.C. van |
2011-12-01
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Artemis splice defects cause atypical SCID and can be restored in vitro by an antisense oligonucleotide
(Article)
IJspeert, H. Lankester, A.C. Dongen, J.J.M. van Gent, D.C. van Burg, M. van der Berg, J.M. van den Wiegant, W.W. Zelm, M.C. van Weemaes, C.M.R. Warris, A. Pan-Hammarström, Q. Pastink, A. Tol, M.J.D. van |
2011-09-01
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Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways
(Article)
Berkowska, M.A. Driessen, G.J.A. Dongen, J.J.M. van Zelm, M.C. van Bikos, V. Grosserichter-Wagener, C. Stamatopoulos, K. Cerutti, A. He, B. Biermann, K. Lange, J.F. Burg, M. van der |
2011-08-25
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IL-7R expression and IL-7 signaling confer a distinct phenotype on developing human B-lineage cells
(Article)
Nodland, S.E. Berkowska, M.A. Bajer, A.A. Shah, N. Ridder, D. de Dongen, J.J.M. van LeBien, T.W. Zelm, M.C. van |
2011-08-25
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Genetic analysis of contiguous X-chromosome deletion syndrome encompassing the BTK and TIMM8A genes
(Article)
Arai, T. Zhao, M. Kanegane, H. Zelm, M.C. van Futatani, T. Yamada, M. Ariga, T. Ochs, H.D. Miyawaki, T. Oh-Ishi, T. |
2011-08-01
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