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tourette patient syndrome family study tourette syndrome linkage gille disorder model ia tourette syndrome analysis wetering bjm van relative psychiatry treatment score marker gts patients symptom result table chromosome wetering dutch behavior group cohen dj addiction control genet disease cocaine use analyses phenotype chapter cocaine raven press subject pauls dl ia tourette frequency exposure segregation kidd kk difference research history woerkom tcam van evidence leckman jf linkage analysis motor number coming diagnosis cohen interview trimester penetrance gts gene press relationship locus sample oostra ba segregation analysis genetic prevalence university inheritance shapiro friedhoff aj population chase tn association partner transmission female finding