Knudsen, J.D.

azithromycin model concentration erythromycin regimen experiment pharmacokinetic survival chemother antimicrob blood serum efficacy result curve pharmacodynamic macrolide antibiotic mouse dosing agents chemother count treatment difference parameter strain pharmacokinetic model pharmacodynamic parameters dosing regimens time-kill experiments suppl study method t 0 h statens serum institut agent pneumococcal effect ed 50s infection time-kill comparison fluid t max-kill analysis 1993. sample 0.03 4 mg /kg girard interval cfu counts 1.2 mouse model t mic table growth one-dose regimen drug concentration pneumoniae 0.5 determination 1990. penicillin culture pneumococci exposure animal value time-kill curves one-dose compartment max-kill number t 1/2s mg /liter h range dose regimens log cfu pharmacodynamic model