Boer, H.A.

glucosidase enzyme mouse expression cho cells gland lysosomal transgene activity production fraction precursor gsdii disease protein tissue fibroblast glucosidase activity 76 kda muscle 1-casein storage medium glycogen sample natl acad cho cell medium enzyme replacement therapy glucosidase gene figure mouse milk number reuser level fragment animal m 6p receptor blot analysis 110 kda precursor gsdii ko mice fraction i enzyme patient therapy probe hopwood heart biochem genetic table receptor antibody sequence replacement a.j.j analysis fraction i promoter copy number placental acid transgene expression anson glucosidase antibodies epithelial cells model gsdii knockout mice glycogenosis type ii concentration rabbit digestion result deficiency knockout placenta lysosomal glycogen storage source lysosomal storage diseases purification rabbit antibodies mouse lines acids research