Hirst, M.C.

instability mouse expansion transmission x syndrome fmr 1 gene mutation length promoter triplet region allele premutation syndrome genet model mouse promoter region trinucleotide change study human mechanism generation disease oostra contraction instabilitie genetic tract deletion mouse model fmrp expression result dna replication agg interruptions number expression sequence replication yeast element structure clone fmr 1 factor xhoi site loxp sites bacteria cgg tract interruption 3 end premutation alleles mouse promoter retardation variation offspring plasmid origin repair recombination germline x polymorphism assay process pcb 66 x patients fmr 1 mrna mutation alleles 3 cgg tract mouse models cis-acting factors genomic assay absence warren polymorphism phenotype strain female characterization graaff