Janknegt, R.A.

hospital antibiotic antibiotic use 100 patient-days number admission patient-day dutch hospitals 100 admissions dutch change resistance increase netherland patient university antimicrobial penicillin trend <0.001 clavulanic acid 2002. university hospitals selection pressure report trimethoprim dutch hospital pharmacies hospital resource indicators length cefazolin antibiotic treatment p value amoxicillin antimicrobial agents derivative pharmacy agent study result period selection surveillance october table decrease lactamase inhibitors cephalosporins sulfonamide 58.5 ddd combination lactamase-resistant penicillins combinations treatment ceftazidim aztreonam imipenem antimicrobial resistance disease macrolide centre 1997-2002 prophylaxi value guideline ciprofloxacin clarithromycin pressure health clavulanic category lincosamide measurement denmark resource clindamycin fluoroquinolone group period 1997 lactamase-sensitive penicillins 47.2 department 58.5 population consumption